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Hyalucomplex Hydrating


Ceramide is a substance commonly found in intercellular lipids of the stratum corneum, and makes up about 50% of the epidermis. Ceramide has very complex structures, and the skin alone contains 300 to 1000 variants of ceramide. The substance is both hydrophilic and lipophilic, which enables it to form a lipid bilayer that improves softness and moisture retention of intercellular lipids. As we age, our skin loses ceramide, which undermines the structure of the lipid bilayer and makes the skin less effective as a protective barrier. Ceramela, a pseudoceramide made from natural yeast and olive oil, can be used as a moisturizing agent for its good skin friendliness. It also helps rebuild lipid bilayer in the stratum corneum, strengthens the skin's protection against irritation, and increases moisture content of the stratum corneum, which in turn corrects roughness and improves smoothness of the skin, allowing it to stay hydrated and plump for extended periods of time.    


A glycoprotein active ingredient extracted, separated, and purified from almonds that still contains fragments of almond protein. Dulcemin contains abundant glutamic acid as well as proline, leucine, serine, arginine, lysine, and histidine; all of which are hydration factors naturally found in the stratum corneum that contribute to the skin's plump and supple texture.


Manufactured by Japanese company Q.P.Corp, Hyalo-Oligo is a small molecule hyaluronic acid produced using patented hydrolyzation technology that breaks down high purity hyaluronic acid into smaller particles with a molecular weight of 6,000-10,000, and a size of 15-25nm (the gap between skin cells is 200-1000nm). This smaller size makes it easier for the acid to pass through and fill cell gaps with adequate moisture to correct dryness.   


After many years of development, the research team at DR.WU introduced the 5th generation of hyaluronic acid (HA) solution called "HyaluComplex," a revolutionary formula that combines macromolecular and small molecule HAs with HA-based hydration factors and OptimHyal (a new polysaccharide of HA). HyaluComplex not only works deep into the skin to awaken key hydration factors, but also replenishes moisture from the outside to keep the skin hydrated for long periods of time.


A patented substance supplied by Sederma from France. It contains a certain percentage of Glycokines™, oligosaccharides of acetylated glucoronic acids, that improve skin conditions. By increasing expression of hyaluronic acid receptor (CD44) on the cell surface, the solution increases the level of hyaluronic acid within the body. It also promotes creation of elastin by the fibroblast, which supports the extracellular matrix and activates the skin's hydration cycle.  

Sodium Hyaluronate

Q.P. Corp, Japan's No. 1 hyaluronic acid manufacturer, produces sodium hyaluronate from non-animal source and uses microorganisms (streptococcus zooepidemicus) to ferment and produce hyaluronic acid in high purity. With an average mass of 1.2 million to 2.2 million Dalton, sodium hyaluronate attracts water up to 1000 times its mass and is able to form a hydration film over the skin surface to keep the stratum corneum hydrated for extended periods of time.  


The substance reacts with proteins on the surface of the skin to protect proteins from degradation. It also stimulates production of hyaluronic acid by the fibroblast to keep the skin hydrated and protected from dry damage, which in turn improves roughness, suppleness, and smoothness of the skin.